DNA: DOES IT SHAPE OUR LIVES?

All human characteristics - from the colour of our hair and even our personality to our physical condition and vulnerability to disease – are to a significant degree defined by the genetic information hidden in our DNA! Genes ­ which are particular segments of the DNA - control traits, characteristics and overall health.

 

WHAT MAKES US DIFFERENT?

Although more than 99% of human DNA is identical among all people, it is the remaining fraction of 1% that makes us each unique. These tiny differences in DNA from person to person are known scientifically as ‘mutations.’ They build our physical identity and define together with the environmental factors our individuality.

 

WHAT IS PREDICTIVE GENOMICS?

Predictive Genomics is the field of medicine that deals with the detection of specific mutations in the DNA, which are associated with certain traits, characteristics or common polygenic – multifactorial diseases.

Personalized ↔ Predictive ↔ Preventive ↔ Participatory

 

WHICH ARE THE BENEFITS FROM PREDICTIVE GENOMICS TESTING?

The ultimate purpose of Predictive Genomics is to pave the way for the appropriate early, and as much as possible individualized and personalized actions in order to

  • Be Healthier & Live Longer
    • Prevention – Risk Reduction
    • Timely, targeted, customized medical, pharmacological, nutritional & environmental intervention
      • Body Weight Management
      • Lifestyle choices for optimal fitness
  • Look Younger and Feel Better
    • Anti-aging
    • Overall sense of “well-being”
  • Achieve optimal sport performance
    • Benefit from natural advantages
    • Overcome genetic barriers

 

WHICH VALUE ADDED SERVICES DO WE OFFER?

We also offer a number of services based on your DNA test results, including:

  • A Personalized Nutritional Consultation and Diet plan for the daily nutritional needs of your body, aiming at a healthy way of living and optimal health according to your personal needs.
  • A Personalized Nutritional Consultation and Diet plan for obesity management, with a calorie restriction diet that does not put your health in danger.
  • A Personalized Nutritional Consultation and Diet plan, which will detail your nutritional requirements during training and competitive events in your sport of choice [Additional information will be required regarding your dietary habits, sport of choice, etc.]
  • A Personalized Training program and Training consultation according to your genetic profile to optimize your athletic performance, taking your sport of choice into account. [Additional information will be required, including an exercise-physiological evaluation and current performance records.

 

Personalized Cosmetics & Nutritional Supplements

Your genetic profile can be used to provide you with personalized nutritional supplements and a personalized line of cosmetics which are:

• 100% organic

• based on the results of your DNA test

• produced to satisfy the specific needs of your body

• necessary in your daily routine for

  • your ongoing nutritional support & general wellbeing
  • efficient weight loss
  • a youthful and healthy appearance
  • your nutritional support when in physical activity

 

HOW THE GENES TO BE TESTED ARE SELECTED?

Gene mutations are - to every extent possible - specifically selected to fulfill the following criteria:

Relevant: The mutation exerts direct influence over the biological system of interest and directly relates to traits, symptom clusters, or disease. The biological effect of the mutation is clearly documented in the scientific literature.

Prevalent: The mutation is relatively common in the general population. These DNA changes are also known also as polymorphisms, representing the gene variants (alternative forms of the genes). Every attempt has been made to exclude mutations with less than 1% population frequency.

Modifiable: The effect of the mutation can - to a significant degree - be modifiable by appliance of the appropriate measures and corrective actions. These could be Medical, Pharmaceutical, Nutritional, Environmental, Life-Style, Training guidelines.

Measurable: The impact of corrective actions that can modify the effects of the mutations is measurable -with the passing of time after applied - by laboratory assays when possible.

 

HOW IS SAMPLING DONE?

  • DNA sampling is painless and does not require blood.
  • It involves taking cells from the inside of your cheeks with specialised and sterilised buccal swabs-one swab for each cheek.-The DNA from these cells will be at the laboratory. extracted and analyzed
  • It is advisable that if you had anything to eat or drink within the last hour before swabbing [including coffee or tea] you should wash your mouth first by swirling water in your mouth and spitting it out two or three times. This assures washing away any existing food particles as well as coffee or tea that sometimes interferes with the required DNA amplification for genotyping.
  • What is really needed from you is an actual scraping-swabbing of the inside of the cheek:

Move the stylus back and forth, up and down and by rotating it alternatively clockwise and counter-clockwise for at least 30 seconds. The process should be repeated in the other cheek

  • Caution is required because the shaft of the swab is not always rigid and can easily bend the cotton tip. In this case it might lose the contact with the epithelium might be and swabbing would be done incorrectly.
  • To assure contact of the cotton tip with the epithelium you can put your finger on the outside of cheek, feel the cotton tip through the skin and apply pressure to it, while swabbing.

 

 

HEALTH & MEDICAL CARE


Cardiovascular health

  • Lipid levels
  • Homocysteine levels
  • Coronary Artery Disease
  • Atrial Fibrillation

 

Type 2 Diabetes

 

Bone health

  • Osteoporosis

 

Inflammatory/Autoimmune Conditions

  • Inflammation
  • Rheumatoid Arthritis
  • Ankylosing Spondylitis
  • Multiple Sclerosis
  • Psoriasis

 

Venous Thromboembolism

 

Atopic Disease – Asthma & Allergy

 

Neoplasia

  • Colorectal Cancer
  • Prostate Cancer
  • Breast Cancer (sporadic)
  • Breast Cancer (familial)
  • Lung Cancer
  • Skin Cancer (Basal Cell Carcinoma)
  • Skin Cancer (Melanoma)

 

Alzheimer’s disease

 

Haemochromatosis

 

Cystic fibrosis

 

Cluster Headaches

 

Periodontitis

 

Eye Diseases

  • Exfoliation Glaucoma
  • Macular Degeneration

 

Depression

 

Pharmacogenomics

  • Triptans
  • Warfarin Sensitivity
  • Aspirin & coagulation
  • Beta blockers & hypertension
  • Beta blockers & heart failure
  • Statins & cholesterol
  • Clopidogrel (Plavix) response and prevention of athero-thrombotic events
  • 5-FU (5-fluorouracil): Toxicity in Cancer chemotherapy
  • Thiopurines: Toxicity in therapy of Leukemia, Chrohn’s disease, Rheumatoid Polyarthritis
  • Tamoxifen: Toxicity in Cancer chemotherapy
  • Asthma drug response
  • Antidepressants

 

Nutrigenomics

  • Lipid metabolism
  • Folic acid metabolism
  • Iron absorption & storage
  • Inflammatory response
  • Anti-oxidation
  • Detoxification
  • Salt Sensitive Hypertension
  • Alcohol metabolism
  • Caffeine metabolism
  • Lactose tolerance
  • Gluten tolerance

 

OBESITY MANAGEMENT & NUTRIGENOMICS


Feeding Behaviour & Energy Balance

 

Lipolysis

 

Obesity & Inflammation

 

Reward Deficiency Syndrome (“Snacking Between Meals”) / Feedback Response Mechanism

 

Nutrigenomics

  • Lipid metabolism
  • Folic acid metabolism
  • Iron absorption & storage
  • Inflammatory response
  • Anti-oxidation
  • Detoxification
  • Salt Sensitive Hypertension
  • Alcohol metabolism
  • Caffeine metabolism
  • Lactose tolerance
  • Gluten tolerance

 

ANTI-AGING & NUTRIGENOMICS


Dermagenomics

  • Collagen Synthesis
  • Skin Anti-oxidation
  • Skin Irritability
  • Skin Detoxification
  • Skin Replenishment
  • Skin Cancer (Basal Cell Carcinoma)
  • Skin Cancer (Melanoma)

 

Early Loss of Hair (both for men and women)

 

Nutrigenomics

  • Lipid metabolism
  • Folic acid metabolism
  • Iron absorption & storage
  • Inflammatory response
  • Anti-oxidation
  • Detoxification
  • Salt Sensitive Hypertension
  • Alcohol metabolism
  • Caffeine metabolism
  • Lactose tolerance
  • Gluten tolerance

 

ATHLETIC PERFORMANCE


Sport Performance

  • Endurance capacity
  • Muscle performance

 

Susceptibility to injuries

  • Tendons
  • Bones

 

Psychological aptitude

 

Substance abuse

 

Body Mass Index

 

Nutrigenomics

  • Lipid metabolism
  • Folic acid metabolism
  • Iron absorption & storage
  • Inflammatory response
  • Anti-oxidation
  • Detoxification
  • Salt Sensitive Hypertension
  • Alcohol metabolism
  • Caffeine metabolism
  • Lactose tolerance
  • Gluten tolerance